any questions about effectiveness on big game can be seen here. unfortunately, its a promo vid so it doesnt actually show the kill shot, but when i saw it on the US based outdoor channel, the bull dropped instantly at the shot.
http://www.youtube.com/watch?v=O_EvNdQ2HUc
this one does show it. if you dont know, an eland bull can easily weigh 1500 pounds. sorry to post an sci influenced vid, but it illustrates the topic here.
http://www.youtube.com/watch?v=FPQ-VOXk2z8
im looking hard for stats for handgun hunting. i cant find it broken down though. i am only coming up with hunting numbers and handgun numbers.....but not both at once.