I have used them for a few years now and have killed about seven animals. All but one have been one shot kills (the one that required 2nd shot was my fault as the shot was back a little far); and ranged from 90 yards out to 450 yards with 300 WM 175 gr VLD. There wasn't much left of the bullets and all but one exited (90 yard did not exit) and all I could find was bits and pieces. There will be damaged meat if you put it in the wrong spot; if you put it in the vitals I don't think it would be any worse than any other bullet.
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