I have used a 30-06 shooting the hornady 165 grain BTSP for over 20 years on everything from antelope to bison. I'm very comfortable out to 400 yards on anything. Bullet placement is most important, find what you and your gun likes and stick with it. I believe a 165 grain projectile is a good all around choice. If a properly placed 165 grain can't kill your target, neither will the 150 or 180 grain.
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