I have used 17 different calibres of rifles (.17 to 375 H&H) to kill about 70 head of game from foxes to moose and a grizzly (not including birds or rodents). Most were taken with 30 calibers and 7mm Mag. I could have done it all with a 22, 7mm Mag. And a 12 gauge but it would not have been near as interesting!