Depending on how well you deal with recoil, the 375 can be considered somewhere between manageable and brutal. With the bigger cartridges, rifle fit becomes much more critical to how recoil is transferred to the shooter.
FWIW, I believe the 338 is probably the best rifle for the bigger varieties of big game in NA (moose, elk, bison, bears), even more so while wandering through grizz country. However, I chose the 375, cause you really can't have too much gun.
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