If you choose your reticle correctly for the trajectory of your load, the reticle will calibrate at close to the maximum magnification of the scope.
If you choose a reticle designed for a cartridge with a flatter trajectory than your load produces, you will need to turn the magnification down to calibrate the reticle. Let's say you go with a Rapid Z800 reticle for a 308win, if the scope is a 4.5-14, it could likely calibrate in the 8x-10x range.
If you choose a reticle designed for a load with a much less flat trajectory, than your load ,you can't properly calibrate it. You can play with the point of impact at 200 yards to try and compensate, but it just won't as well as it is designed to do. An example would be using an RZ600 on a 22-250.
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