[Sitting Bull]

I have a BLR81 in .308. I am trying to develop a load for it today. I have loaded up 2 types of powder and was not able to get an acceptable grouping at the range today.
Rifle bore clean, Full length brass, CCI 200 primers, O.A.L. 2.750", Sierra 165gr spitzers and IMR 4320 with load specification directly from Hodgdon site.
Same as above except my second powder choice that I had on hand H4895. Again from Hodgdon web site I started with min to max.
H4895 was much better than IMR 4320,
The best group with H4895 was at 42.0 gr and 42.5gr with a 3 shot group 2 were ok and the third would fly.
Which direction should I go from here? A different powder? Which one? Seat the bullet deeper in the case? By how much? Try different bullet? Again which ones? I am out of 165's now so I am open to suggestions.
The scope is a Leupold M8 6x36 recently checked over by Korth. Everything nice and tight. No signs of excessive pressure on the primer either.
Sorry for all the questions, but I do not have a whole bunch of experience re loading .
Thanks for the help.
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