In my experience it depends on the bow and the shooter.
A bow will work at is “peak efficiency” if it’s setup to be used at its peak weight. That’s not to say you can’t tune and adequately shoot a bow that is not at peak weight.
If a shooter struggles to meet the peak weight of a bow, the whole system breaks down. Shoot a weight that is comfortable in all scenarios, especially a hunting bow. Focus on the “one shot” aspects. If you cannot shoot a heavier poundage well or comfortably you will just miss or wound faster.
LC