No such thing as too dead they say, so shoot as big as you want. Said this before, and though I don't own one (prefer my .338-06), if I could only have one rifle for everything on this continent and a whole pile of others it'd be a .338 Win Mag shooting 250 Partitions for the big stuff and 210's to 225's for everything else. Load it down or to the teeth and very little on earth can't be taken pretty cleanly with the .338
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