.22, rimfire, affordable ammo ($20 for 500 rds), fun to shoot, low velocity, short range, plinking, squirrels, gophers, rabits, chickens. A 10/22 is not a calibre it is a semi-auto .22 cal rifle made by Ruger.
22.250 is in a different class altogether, centre-fire, high priced ammo, high velocity, longer range, varmint rifle.
.17 hmr, rimfire, $140 for 500 rds, fun to shoot, high velocity.... shoots way faster and further than a .22.....200 yards easily, light .17 and .20 gr bullets drift with winds..... otherwise deadly accurate rounds.
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