I have used Varget, H4831SC and IMR 4350, all with good results, but the IMR4350 is what works for us the best. We use a Browning X Bolt in the 25-06 Rem. Every gun will be different, so try small loads of different powders, and different grains, see what works best for you. Once you have a consistent group, you are good to go!
Reloading can be can be a bit of trial and error to get a load that works. My Grandfather had (and my dad still has) a 257 Roberts that he custom built for a guy years ago. The guy could not get a group out of it, so my Grandfather took it back, and worked with it for quite a while until he got a load that works. To this day, that is the load and bullet, that we use for it, nothing else. I took many deer with that rifle as a kid!
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