I've shot coyotes with a Ruger #1 in .223 for years. It is boringly deadly out to about 300 yds. Longest shot I made was 406 yds. He was graveyard dead. I've shot lots around the 300 yard mark as well. Having said that I don't think it is a long range caliber. I also find it fur friendly as long as you stay off the bone.
I have a 220 Swift when I want to dress up and reach out. I try not to shoot anything inside 200 yds as it is not as furgiving [see what I did there? lol] as the .223 Stay off the shoulder and hit them in the boiler and there's not much stitching.
It isn't bad and I find it better than the 22.250 for terminal performance even though the ballistics charts on the 220 and the 2.250 are very similar.
If I had to choose between the .223 and the 22.250 to put fur on the board , i'd choose the .223 all day long. But if I had to choose between the 220 and the .223 I'd choose the 220 cause I look so good, shooting it.