Shooting coyotes even for fur with the right bullet selection i have found the 22-250 to be just as fur friendly as 223. You must pick a highly frangible bullet though such as the tnt or varmint grenade. I recently switched to the nobler varmageddon and am expecting similar results. for factory economical ammo options the winchester white box hollow points have been very accurate and fur friendly for me. One thing I've noticed with .223 and even light (36gr) 22-250 bullets is Yes they will kill coyotes no problem but there are definitely more coyotes that require some tracking and far less bang flops than with a 55gr 22-250 bullet.
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