If you already have the 22-250 then just use your 10x scope and get out there and start hunting. I have been using a variety of 90-107 grain bullets in my 6mm and so far I have yet to see one that doesn't dang near cut em in half and I don't see that changing in 6.5.
My "go to" calling rifle wears a standard cheap 3x9 scope and it almost never comes off of 9x so your fixed 10 won't be as bad as you think.
As far as long range shooting on coyotes. Probably %90 of the shots you get at coyotes are under 400 yards and with a tikka 22-250 you should be able to get a gun accurate enough to do that job just fine.
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life's too short to fish nymphs
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