Every gun will shoot a different way. Heavy, or bullets that are long in comparison to their calibre, should be used in rifles with a faster rate of twist, lighter bullets can have a slower rate of twist.
It will not make much difference on a hunting rifle. It really only makes a difference in long range, bench rest or tactical shooting.
My 308 target rifle will drop anything from 150 to 180 grain into the same holes at targets within 300 metres. The variation is only noticable, and becomes much more apparent with each additional 100 metre range. Ideally this rifle is intended for 140-160 grain at the longer ranges.
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