In my experience, and I've shot hundreds of coyotes, go with a 243 shooting a 100 grain deer bullet.
I've used the 204 and have had way too many runners. I've hit em good too, right in the boiler room and they have a tendency to run off, more than I like.
The 22-250 is fine but it makes a mess of em, even you hit em right. Too fast.
243, shooting a 100 grain sako gamehead, I've had my best yr on pelts. I should've taken pics to show. But man, this year was my easiest year on pelts using that bullet. And no big bleed out either. Just a nice little hole in and out. And it lays em down. They don't move, they don't run, they just die.
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