What I know of bullets is that II have killed animals with everything from pure lead round balls too hard cast lead bullets to cup and core cheap bullets to stuff like Barnes XLC's in calibers ranging from .224 to .570 with both black and smokeless, and muzzle loading to modern cartridges and everything in between.
All the animals over the years died quickly if I hit them where I was aiming, no matter what I was shooting.
I also had some tracking to do if they were not hit where was aiming no matter what I was shooting.
The caliber of a rifle is the last thing I look at when deciding if I want to hunt with a particular rifle.
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Anytime I figure I've got this long range thing figured out, I just strap into the sling and irons and remind myself that I don't! 
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