What kind of hunting do you do? Are you recoil sensitive? I like the 7mm-08 for deer and the 300 WSM for the bigger stuff. Both of these cartridges are very efficient and intrinsically accurate.

To answer the question, I would choose the .308 as it served me well for many years (untill I wore it out) and meets the above criteria. Both cartridges are awesome and you can't go wrong.

R