I've been hunting with Nosler Ballistic Tips since starting to reload several years ago. The bullet goes in and doesn't come out on broadside shots resulting in bang-flops or deer that drop after 50 yds. They turn lungs into mush. I watched the gelatin tests on youtube and I'm quite confident that the bullets would be effective in the event of a shoulder shot through bone.
I know that it'll come up so I guess that I should mention that I am not overly concerned about any residual lead left over in the animals that I shoot.