Good Question...Two shooters of same draw...shoot same bow and arrow...same release...two different results...so form has a lot to play..biggest being grip and follow thru..
Bow spec tuned, tuned to arrow and rest arrow OC [on center] berger 13/16 from riser...nocked 1/4 above square of bottom of rest...[ 90 degrees 1/4above] is arrow perfectly OC and square...
However with some shooters and set up that may not be the sweet spot for the bow and/or shooter so rest, nock point may need to be moved to achieve perfect flight...no problem move them!
In fact many Solo cams like to be slightly nock high, I usually set them at 5/16 instead of 1/4...making some arrow in rest looking arrow tip down or nock up.
I am kinna anal about having arrow centered on Berger in rest [rest bolt hole/insert] ...the Berger is the center of the bows universe and designed around it....
One can move rest up or down to achive the desired flight...which I will do...but once I find that..I will move the rest back to arrow OC on berger and than move nock point for same final results
It may be a little more of a hassle to move loop and peep...but once its done bow is OC or center shot...
Moving rest left or right is perfectally acceptable and hows its done to achive arrow flight...as long as its not extreme...meaning too close to riser causing clearance issues or too far out from riser [1" for example]..other issues are at play and need to be looked at and worked out...
But to answer your question ...no it doesnt matter if center shot is slightly high/low or left /right for the shooter or bow...AS LONG as it isnt extreme
in tuning broadheads to field points most end up off perfect center shot or "square" pending on shooter and set up
Clear like mud? lol
Neil