22-250 is the way to go
I've tried the 6mm (similar to the 243), 223, and 25-06. I now have a 22-250 and think that it is the best all around coyote round. It slams the coyote down in a hurry (much better than the 223) and does not harm the fur like the 25-06 or 6mm. Until you try it, you will not believe how ideal it is for coyotes.
The only other caliber, I wouldn't mind trying, is the 204 Ruger, but the 22-250 is working so good for me, I probably never will.
If I lived and called regularily where there are lots of bears and cougar, I might consider a 243, just in case a large predator decided to make me lunch.
I really like the 22-250 with 55 gr VMax bullets. Try it, you'll like it!
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