I was in Vegas 2 years ago and did try lake Mead. Ended up catching some catfish there with a pickeral rig.
My advice would be to fish off one of the big rock points. In the evening right as it gets dark there were stripped bass everywhere even within a few feet of shore. You can see them swimming just under the surface sometimes. And they get pretty big too, saw some that were in the 20-30lb range but they didn't seem interested in any lures. Caught one little guy on a silver castmaster
Also at sunrise in the bays, the water was boiling with what I'm guessing were carp surface feeding, never caught what was jumping so much though.
In general I would recommend and outcrops where it's deep and right around sunrise/sunset.
Hope that helps
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