Accuracy - yes but no. Yes in that altitude, temperature and humidity do affect flight time and therefore POI
No in that you won’t see a measurable difference under 400 yards, on a deer, shot from a field position
You can use 500 yards and 5000’ feet of elevation change as a general rule, that’s about the point I would pull out the phone app and enter environmentals. On shorter shots, the bullet isn’t in the air long enough to be more than .2 MOA off.
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