Yeah...what the Cat said !!!
Get your velocity first then play from there.
Personally in my 250s ( Savage LRPV and Sako 85 ) I prefer the 55gr stuff ...Nosler BTs and Sierra Blitz Kings. Savage for long range gophers and the Sako is my dog gun.
I made up my own bullet seating device...couldn't find a stoney poit when I initially went looking.